The best Side of cees dekker
The best Side of cees dekker
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Spatial composition facilitates cooperation inside of a social Predicament: empirical proof from the bacterial Group
But how do morality, the dignity from the individual, my expertise from the indicating of lifetime, adhere to in the motion of atoms? A purely naturalistic perspective fails below; a Christian viewpoint, I feel, is a much more reasonable technique to interpret these facets of reality.’
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
2007, very first serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence length of ends of microtubules; and solved the system of biosensing with carbon nanotubes
2015, discovery that condensin is usually a remarkably flexible protein composition; and initially detection of DNA knots making use of nanopores
The coiled-coil from the human Rad50 DNA maintenance protein is made up of particular segments of increased overall flexibility
Because 2000 he moved to one-molecule biophysics and nanobiology, with exploration from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation by means of nanopores. Lately his investigate has centered on studying mobile division with microorganisms on chip, although his ultimate fascination is from the route of realizing artificial cells.
2000, discovery that nanotubes can have extraordinary massive present-day densities; resolved the controversial challenge of electronic transport by way of DNA molecules by measurements of insulating actions at the single molecule degree; and demonstration of the AFM technique for single-molecule manipulation of nanotubes
Understanding essential procedures regulating the spatial and dynamic organisation of the DNA in live cells.
‘The fantastically subtle way wherein things in character operate by no means ceases to amaze me. If we resolve the puzzle of how everyday living arrived into currently being, I count on that my amazement at the complexity of generation will likely have improved and with it my awe for the greatness of your Creator.’
Screening pseudotopological and nontopological styles for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
‘That problems the artificial mobile, as part of the Dutch BaSyC initiative. Craig Venter looked best-down in These days and recognized about 5 hundred genes which have been minimally necessary to get a operating mobile. We want to search base-up: how can we move from a several molecules to a complete biological technique?
Visualization of unstained DNA nanostructures with Innovative in-concentration transmission electron microscopy procedures
Good-point out nanopores ceesdekker.net have tested to be a surprisingly flexible probe for single-molecule analysis of DNA. I will explain many of our the latest conclusions – precisely DNA knots – and our endeavours to develop the abilities of sound-state nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.